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Tau is a microtubule-associated protein with multiple splice forms found primarily in neurons. Hyperphosphorylated tau is the major component of paired helical filaments and other large intracellular aggregates in the brains of patients with Alzheimer's disease and some other neurodegenerative disorders. The Phospho(Thr231)/Total Tau Kit provides assay-specific components for the quantitative determination of phospho-tau (Thr231) and total tau in human and mouse brain homogenates and tissue culture supernatants.
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Specifications
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Kit Contents
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Documentation
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References
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Application(s)
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Alzheimer’s Disease
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Phosphoproteins
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Neurobiology/Neurodegeneration
,
Intracellular Signaling
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Analyte(s)
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Tau (pT231), Tau (total)
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Species
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Human, Mouse
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Instrument(s)
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SECTOR Imager 2400
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MESO SECTOR S 600MM
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SECTOR Imager 6000
,
MESO QuickPlex SQ 120MM
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MESO QuickPlex SQ 120
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MESO SECTOR S 600
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Plate Type
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96-well
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LLOD (Sensitivity)
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Phospho-Tau: 0.09 units
Total Tau: 0.05 ng/mL
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Dynamic Range
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Phospho-Tau: 0.09-50 units
Total Tau: 0.05-1000 ng/mL
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Statement(s)
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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Multi-Component
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Schedule B Code
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3002.15.0100
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Product Description
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Storage
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Quantity per Kit
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Tau441 Calibrator (phosphorylated)
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≤-70 °C
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1 vial
(15 μL)
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SULFO-TAG Anti-Total Tau Antibody
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2-8 °C
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1 vial
(100 μL)
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Phospho(Thr231)/Total Tau Plate
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2-8 °C
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1 each
(1 each)
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2-8 °C
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1 bottle
(200 mL)
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RT
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1 bottle
(50 mL)
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RT
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1 bottle
(15 g)
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≤-10 °C
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1 vial
(0.25 mL)
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Product Description
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Storage
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Quantity per Kit
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Tau441 Calibrator (phosphorylated)
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≤-70 °C
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5 vial
(15 μL)
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SULFO-TAG Anti-Total Tau Antibody
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2-8 °C
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1 vial
(500 μL)
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Phospho(Thr231)/Total Tau Plate
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2-8 °C
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5 each
(1 each)
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2-8 °C
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1 bottle
(200 mL)
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RT
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1 bottle
(50 mL)
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RT
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1 bottle
(15 g)
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≤-10 °C
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1 vial
(0.25 mL)
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Product Description
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Storage
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Quantity per Kit
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Tau441 Calibrator (phosphorylated)
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≤-70 °C
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20 vial
(15 μL)
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SULFO-TAG Anti-Total Tau Antibody
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2-8 °C
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4 vial
(500 μL)
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Phospho(Thr231)/Total Tau Plate
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2-8 °C
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20 each
(1 each)
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2-8 °C
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1 bottle
(1000 mL)
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RT
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1 bottle
(200 mL)
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RT
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1 bottle
(15 g)
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≤-10 °C
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4 vial
(0.25 mL)
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Product Inserts
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Datasheets
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Certificate of analysis
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SDS
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Title
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Journal
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Year
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Plasma biomarkers for diagnosis of Alzheimer’s disease and prediction of cognitive decline in individuals with mild cognitive impairment
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Changes in Amyloid-β and Tau in the Cerebrospinal Fluid of Transgenic Mice Overexpressing Amyloid Precursor Protein.
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High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia.
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Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer's disease pathology in TgSwDI and 3xTg mouse models.
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The AD-CSF-Index discriminates Alzheimer's disease patients from healthy controls: A validation study
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