Search For Scientific Publications - Meso Scale Discovery

Research laboratories and drug development companies around the world use MSD technology to analyze disease states through the characterization and quantification of biomarkers. We maintain a list of scientific journal articles that describe how MSD assays have been instrumental in providing highly sensitive, quantified, reproducible results.

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Title	Journal	Year
Hepatic Deletion of SIRT1 Decreases Hepatocyte Nuclear Factor 1alpha/Farnesoid X Receptor Signaling and Induces Formation of Cholesterol Gallstones in Mice. Purushotham A, Xu Q, Lu J, Foley JF, Yan X, Kim DH, Kemper JK, Li X.	Mol Cell Biol.	2012
Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion. Kyriazis GA, Soundarapandian MM, Tyrberg B.	Proc Natl Acad Sci U S A.	2012
Acute phase response, inflammation and metabolic syndrome biomarkers of Libby asbestos exposure. Shannahan JH, Alzate O, Winnik WM, Andrews D, Schladweiler MC, Ghio AJ, Gavett SH, Kodavanti UP.	Toxicol Appl Pharmacol.	2012
Novel Biological Action of the Dipeptidylpeptidase-IV Inhibitor, Sitagliptin, as a Glucagon-Like Peptide-1 Secretagogue. Sangle GV, Lauffer LM, Grieco A, Trivedi S, Iakoubov R, Brubaker PL.	Endocrinology.	2012
The novel DPP-4 inhibitors linagliptin and BI 14361 reduce infarct size after myocardial ischemia/reperfusion in rats. Hocher B, Sharkovska Y, Mark M, Klein T, Pfab T.	Int J Cardiol.	2012
Trabecular bone loss after administration of the second-generation antipsychotic risperidone is independent of weight gain. Motyl, K.J., Dick-de-Paula, I., Maloney, A.E., Lotinun, S., Bornstein, S., de Paula, F.J., Baron, R., Houseknecht, K.L., Rosen, C.J.	Bone.	2012
Mechanisms Underlying Metformin-Induced Secretion of Glucagon-Like Peptide-1 from the Intestinal L Cell. Mulherin, A.J., Oh, A.H., Kim, H., Grieco, A., Lauffer, L.M., Brubaker, P.L.	Endocrinology.	2011
GPR119 agonists mediate GLP-1 secretion from mouse enteroendocrine cells through glucose-independent pathways. Lan, H., Lin, H.V., Wang, C.F., Wright, M.J., Xu, S., Kang, L., Juhl, K., Hedrick, J.A., Kowalski, T.J.	Br J Pharmacol.	2011
Inhibition of Apical Sodium-Dependent Bile Acid Transporter (Asbt) as a Novel Treatment for Diabetes. Chen, L., Yao, X., Young, A., McNulty, J., Anderson, D., Liu, Y., Nystrom, C., Croom, D., Ross, S., Collins, J., Rajpal, D., Hamlet, K., Smith, C.D., Gedulin, B.R.	Am J Physiol Endocrinol Metab.	2011
Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice. Stanton, M.C., Chen, S.C., Jackson, J.V., Rojas-Triana, A., Kinsley, D., Cui, L., Fine, J.S., Greenfeder, S., Bober, L.A., Jenh, C.H.	J Inflamm.	2011
Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice. Sugimoto, H., Okada, K., Shoda, J., Warabi, E., Ishige, K., Ueda, T., Taguchi, K., Yanagawa, T., Nakahara, A., Hyodo, I., Ishii, T., Yamamoto, M.	Am J Physiol Gastrointest Liver Physiol.	2010
Trans fat feeding results in higher serum alanine aminotransferase and increased insulin resistance compared with a standard murine high-fat diet. Koppe, S.W., Elias, M., Moseley, R.H., Green, R.M.	Am J Physiol Gastrointest Liver Physiol.	2009
Novel pharmacological MC4R agonists can efficiently activate mutated-MC4R from obese patients with impaired endogenous agonist response. Roubert, P., Dubern, B., Plas, P., Lubrano-Berthelier, C., Alihi, R., Auger, F., Deoliveira, D.B., Dong, J.Z., Basdevant, A., Thurieau, C., Clement, K.	J Endocrinol.	2010
Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice. Yang, R., Wilcox, D.M., Haasch, D.L., Jung, P.M., Nguyen, P.T., Voorbach, M.J., Doktor, S., Brodjian, S., Bush, E.N., Lin, E., Jacobson, P.B., Collins, C.A., Landschulz, K.T., Trevillyan, J.M., Rondinone, C.M., Surowy, T.K.	J Biol Chem.	2007
Essential Role for Protein Kinase C{zeta} in Oleic Acid-Induced Glucagon-Like Peptide-1 Secretion in Vivo in the Rat. Iakoubov, R., Ahmed, A., Lauffer, L.M., Bazinet, R.P., Brubaker, P.L.	Endocrinology	2011
Effects of peripherally administered neuromedin U on energy and glucose homeostasis. Peier, A.M., Desai, K., Hubert, J., Du, X., Yang, L., Qian, Y., Kosinski, J.R., Metzger, J.M., Pocai, A., Nawrocki, A.R., Langdon, R.B., Marsh, D.J.	Endocrinology	2011
A pilot study to assess whether glucagon-like Peptide-1 protects the heart from ischemic dysfunction and attenuates stunning after coronary balloon occlusion in humans. Read, P.A., Hoole, S.P., White, P.A., Khan, F.Z., O'Sullivan, M., West, N.E., Dutka, D.P.	Circ Cardiovasc Interv.	2011
Cardioprotection against ischaemia induced by dobutamine stress using glucagon-like peptide-1 in patients with coronary artery disease. Read, P.A., Khan, F.Z., Dutka, D.P.	Heart.	2011
Duodenal-jejunal bypass protects GK rats from {beta}-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1. Speck, M., Cho, Y.M., Asadi, A., Rubino, F., Kieffer, T.J.	Am J Physiol Endocrinol Metab.	2011
The effect of antioxidant supplementation on insulin-sensitivity in response to endurance exercise training. Yfanti, C., Nielsen, A.R., Akerstrom, T.C., Nielsen, S., Rose, A.J., Richter, E.A., Lykkesfeldt, J., Fischer, C.P., Pedersen, B.K.	Am J Physiol Endocrinol Metab.	2011
Postnatal PPARd Activation and Myostatin Inhibition Exert Distinct yet Complimentary Effects on the Metabolic Profile of Obese Insulin-Resistant Mice. Bernardo, B.L., Wachtmann, T.S., Cosgrove, P.G., Kuhn, M., Opsahl, A.C., Judkins, K.M., Freeman, T.B., Hadcock, J.R., LeBrasseur, N.K.	PLoS One	2010
Kinetic Assessment and Therapeutic Modulation of Metabolic and Inflammatory Profiles in Mice on a High-Fat and Cholesterol Diet. Engstrom, L.W., Bober, L., Chen, S., Fine, J.S., Ying, L., Stanton, M.C., Kinsley, D., Cui, L., Jackson, J.V., Rojas-Triana, A., Lundell, D., Laverty, M., Gustafson, E.L., Jenh, C., Kowalski, T.J., Manfra, D.J.	PPAR Research.	2010
The Metabolic Phenotype of Prader-Willi Syndrome (PWS) in Childhood: Heightened Insulin Sensitivity Relative to Body Mass Index. Haqq, A.M., Muehlbauer, M.J., Newgard, C.B., Grambow, S., Freemark, M.	J Clin Endocrinol Metab.	2010
Cholinergic augmentation of insulin release requires ankyrin-B. Healy, J.A., Nilsson, K.R., Hohmeier, H.E., Berglund, J., Davis, J., Hoffman, J., Kohler, M., Li, .LS., Berggren, P.O., Newgard, C.B., Bennett, V.	Sci Signal.	2010
Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity related co-morbidities. Kohli, R., Kirby, M., Setchell, K.D., Jha, P., Klustaitis, K., Woollett, L.A., Pfluger, P.T., Balistreri, W.F., Tso, P., Jandacek, R.J., Woods, S.C., Heubi, J.E., Tschoep, M.H., D'Alessio, D.A., Shroyer, N.F., Seeley, R.J.	Am J Physiol Gastrointest Liver Physiol.	2010

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