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Enter author, analyte, or keyword to search publications.
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| Hall, A., Elliott, R.L., Giblin, G.M., Hussain, I., Musgrave, J., Naylor, A., Sasse, R., Smith, B. (2010) Piperidine-derived gamma-secretase modulators. Bioorg Med Chem Lett. Vol. 20(3):1306-11.
Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40, Abeta42, Aß42, A-beta42, A-ß42, Abeta 42, Aß 42, Ab42, gamma secretase inhibitor, beta secretase
Analytes tested using MSD® assays: Abeta40, Abeta42
Matrix tested: SHSY5Y human neuroblast cell lysates
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| Jesse, S., Steinacker, P., Lehnert, S., Sdzuj, M., Cepek, L., Tumani, H., Jahn, O., Schmidt, H., Otto, M. (2010) A Proteomic Approach for the Diagnosis of Bacterial Meningitis. PLoS One. 2010; 5(4): e10079.
APP, amyloid precursor protein, sAPP, sAPPa, sAPPb, sAPPa, sAPPß, APP-alpha, APP-beta, APP alpha, APP beta, CSF
Analytes tested using MSD assays: soluble APPalpha, soluble APPbeta
Matrix tested: Human cerebrospinal fluid
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| Luheshi, L.M., Hoyer, W., de Barros, T.P., Hard, I.V., Brorsson, A., Macao, B., Persson, C., Crowther, D.C., Lomas, D.A., Stahl, S., Dobson, C.M., Hard, T. (2010) Sequestration of the Aß Peptide Prevents Toxicity and Promotes Degradation In Vivo. PLoS Biol. 2010 March; 8(3): e1000334.
Abeta42, Aß42, A-beta42, A-ß42, Abeta 42, Aß 42, Ab42, affibody, binding protein
Analytes tested using MSD assays: Abeta42
Matrix tested: Drosophila brain lysates
Special Techniques: Guanidine hydrochloride extraction
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| Wanngren, J., Frånberg, J., Svensson, A.I., Laudon, H., Olsson, F., Winblad, B., Liu, F., Näslund, J., Lundkvist, J., Karlström, H. (2010) The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing. J Biol Chem. 2010 Mar 19;285(12):8527-36. Epub 2010 Jan 27.
Abeta38, Aß38, A-beta38, A-ß38, Abeta 38, Aß 38, Ab38, Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40, Abeta42, Aß42, A-beta42, A-ß42, Abeta 42, Aß 42, Ab42
Analytes tested using MSD assays: Abeta38, Abeta40, Abeta42, total Abeta
Matrix tested: Cell culture medium
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| Eisele, Y.S., Bolmont, T., Heikenwalder, M., Langer, F., Jacobson, L.H., Yan, Z.X., Roth, K., Aguzzi, A., Staufenbiel, M., Walker, L.C., Jucker, M. (2009) Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation. Proc Natl Acad Sci U S A. Vol. 106(31):12926-31.
Abeta38, Aß38, A-beta38, A-ß38, Abeta 38, Aß 38, Ab38, Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40, Abeta42, Aß42, A-beta42, A-ß42, Abeta 42, Aß 42, Ab42
Analytes tested using MSD assays: Abeta38, Abeta40, Abeta42
Matrix tested: Transgenic mouse brain extracts
Special Techniques: Formic acid extraction
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| Fagan, A.M., Mintun, M.A., Shah, A.R., Aldea, P., Roe, C.M., Mach, R.H., Marcus, D., Morris, J.C., Holtzman, D.M. (2009) Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease. EMBO Mol Med. Vol. 1(8-9):371-80.
Abeta38, Aß38, A-beta38, A-ß38, Abeta 38, Aß 38, Ab38, CSF
Analytes tested using MSD assays: Abeta38
Matrix tested: Human cerebrospinal fluid
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| Grathwohl, S.A., Kälin, R.E., Bolmont, T., Prokop, S., Winkelmann, G., Kaeser, S.A., Odenthal, J., Radde, R., Eldh, T., Gandy, S., Aguzzi, A., Staufenbiel, M., Mathews, P.M., Wolburg,H., Heppner, F.L., Jucker, M. (2009) Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat Neurosci. 12(11):1361-3.
Abeta38, Aß38, A-beta38, A-ß38, Abeta 38, Aß 38, Ab38, Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40, Abeta42, Aß42, A-beta42, A-ß42, Abeta 42, Aß 42, Ab42
Analytes tested using MSD assays: Abeta38, Abeta40, Abeta42
Matrix tested: Transgenic mouse brain extracts
Special Techniques: Formic acid extraction of lysates
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| Gisslén, M., Krut, J., Andreasson, U., Blennow, K., Cinque, P., Brew, B.J., Spudich, S., Hagberg, L., Rosengren, L., Price, R.W., Zetterberg, H. (2009) Amyloid and tau cerebrospinal fluid biomarkers in HIV infection. BMC Neurol. Vol. 9: 63.
APP, amyloid precursor protein, sAPP, sAPPa, sAPPb, sAPPa, sAPPß, APP-alpha, APP-beta, APP alpha, APP beta, CSF
Analytes tested using MSD assays: soluble APPalpha, soluble APPbeta
Matrix tested: Human cerebrospinal fluid
Note: Cerebrospinal fluid biomarkers related to amyloid and tau metabolism were measured in HIV-infected patients
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| Hansson, S.F., Andréasson, U., Wall, M., Skoog, I., Andreasen, N., Wallin, A., Zetterberg, H., Blennow, K. (2009) Reduced levels of amyloid-beta-binding proteins in cerebrospinal fluid from Alzheimer's disease patients. J Alzheimers Dis. Vol. 16(2):389-97.
Abeta38, Aß38, A-beta38, A-ß38, Abeta 38, Aß 38, Ab38, Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40, Abeta42, Aß42, A-beta42, A-ß42, Abeta 42, Aß 42, Ab42, CSF
Analytes tested using MSD assays: Abeta38, Abeta40, Abeta42
Matrix tested: Human cerebrospinal fluid
Note: Abeta binding proteins in cerebrospinal fluid were examined to determine if they play a role in preventing Alzheimer’s disease
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| Holmes, C., Cunningham, C., Zotova, E., Woolford, J., Dean, C., Kerr, S., Culliford, D., Perry, V.H. (2009) Systemic inflammation and disease progression in Alzheimer disease. Neurology, Vol. 73:768–774.
TNF-a, TNFa, TNF-a, TNF-a, TNFalpha
Analytes tested using MSD assays: TNF-alpha
Matrix tested: Human serum
Note: Study tests the effect of inflammation associated with Alzheimer’s disease
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Klafki, H.W., Lewczuk, P., Kamrowski-Kruck, H., Maler, J.M., Müller, K., Peters, O., Heuser, I., Jessen, F., Popp, J., Frölich, L., Wolf, S., Prinz, B., Luckhaus, C., Schröder, J., Pantel, J., Gertz, H.J., Kölsch, H., Müller, B.W., Esselmann, H., Bibl, M., Kornhuber, J., Wiltfang, J. (2009) Measurement of ERK 1/2 in CSF from Patients with Neuropsychiatric Disorders and Evidence for the Presence of the Activated Form. Alzheimers Dis. 2009 Jul 20. [Epub ahead of print].
Analytes tested using MSD assays: Phospho ERK (T/Y:202/2046; 185/187), Total ERK1/2 assays
Matrix tested: Human cerebrospinal fluid
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| Mattsson, N., Axelsson, M., Haghighi, S., Malmeström, C., Wu, G., Anckarsäter, R., Sankaranarayanan, S., Andreasson, U., Fredrikson, S., Gundersen, A., Johnsen, L., Fladby, T., Tarkowski, A., Trysberg, E., Wallin, A., Anckarsäter, H., Lycke, J., Andersen, O., Simon, A.J., Blennow, K., Zetterberg, H. (2009) Reduced cerebrospinal fluid BACE1 activity in multiple sclerosis. Mult Scler. Vol. 15(4):448-54.
APP, amyloid precursor protein, sAPP, sAPPa, sAPPb, sAPPa, sAPPß, APP-alpha, APP-beta, APP alpha, APP beta, CSF
Analytes tested using MSD assays: soluble APPalpha, soluble APPbeta
Matrix tested: Human cerebrospinal fluid
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| McLeod, J., Curtis, N., Lewis, H.D., Good, M.A., Fagan, M.J., Genever, P.G. (2009) {gamma}-Secretase-dependent cleavage of amyloid precursor protein regulates osteoblast behavior.FASEB J. Vol. 23(9):2942-55.
Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40, Abeta42, Aß42, A-beta42, A-ß42, Abeta 42, Aß 42, Ab42
Analytes tested using MSD assays: Abeta40, Abeta42 (customer developed assays on MSD avidin plate)
Matrix tested: Culture medium from human multipotent stromal cells / mesenchymal stem cells
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Portelius, E., Brinkmalm, G., Tran, A., Andreasson, U., Zetterberg, H., Westman-Brinkmalm, A., Blennow, K., Ohrfelt, A. (2009) Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluid. Experimental Neurology [Epub ahead of print].
Note: In this study, sAPPalpha standard was obtained from MSD sAPPalpha assay kit to be used in Western Blot
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| Rival, R., Page, R.M., Chandraratna, D.S., Sendall, T.J., Ryder, E., Liu, B., Lewis, H., Rosahl, T., Hider, R., Camargo, L.M., Shearman, M.S., Crowther, D.C., Lomas, D.A. (2009) Fenton chemistry and oxidative stress mediate the toxicity of the ß-amyloid peptide in a Drosophila model of Alzheimer's disease. Eur J Nuroscience. Vol. 29(7): 1335-1347.
Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40, Abeta42, Aß42, A-beta42, A-ß42, Abeta 42, Aß 42, Ab42
Analytes tested using MSD assays: Abeta42 (customer developed assays on MSD plate)
Matrix tested: Drosophila brain extracts
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| Steinacker, P., Hendrich, C., Sperfeld, A.D., Jesse, S., Lehnert, S., Pabst, A., von Arnim, C.A., Mottaghy, F.M., Uttner, I., Tuman, H., Ludolph, A., Otto, M. (2009) Concentrations of beta-amyloid precursor protein processing products in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration. J Neural Transm. 116(9):1169-78. Epub 2009 Aug 1.
Abeta38, Aß38, A-beta38, A-ß38, Abeta 38, Aß 38, Ab38, Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40, Abeta42, Aß42, A-beta42, A-ß42, Abeta 42, Aß 42, Ab42, APP, amyloid precursor protein, sAPP, sAPPa, sAPPb, sAPPa, sAPPß, APP-alpha, APP-beta, APP alpha, APP beta, CSF
Analytes tested using MSD assays: Abeta38, Abeta40, Abeta42, soluble APPalpha, soluble APPbeta
Matrix tested: Human cerebrospinal fluid
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| Steinkellner, H., Scheiber-Mojdehkar, B., Goldenberg, H., Sturm, B. (2009) A high throughput electrochemiluminescence assay for the quantification of frataxin protein levels. Anal Chim Acta.Vol. 659(1-2):129-32.
Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disease, CSF
Analytes tested using MSD assays: Customer developed assay on MSD High Bind plates to measure Frataxin protein levels
Matrix tested: Human lymphoblast cell lysates, human fibroblast cell lysates, HeLa cell lysates, mouse liver cell lysates, mouse brain lysates
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| Vetrivel, K.S., Meckler, X., Chen, Y., Nguyen, P.D., Seidah, N.G., Vassar, R., Wong, P.C., Fukata, M., Kounnas, M.Z. Thinakaran, G. (2009) Alzheimer Disease A{beta} Production in the Absence of S-Palmitoylation-dependent Targeting of BACE1 to Lipid Rafts. J Biol Chem. Vol. 284(6):3793-803.
APP, amyloid precursor protein, sAPP, sAPPb, sAPPß, APP-beta, APP beta
Analytes tested using MSD assays: soluble APPbeta assay
Matrix tested: Cell culture supernatants
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| Welge V, Fiege O, Lewczuk P, Mollenhauer B, Esselmann H, Klafki HW, Wolf S, Trenkwalder C, Otto M, Kornhuber J, Wiltfang J, Bibl M. (2009) Combined CSF tau, p-tau181 and amyloid-beta 38/40/42 for diagnosing Alzheimer's disease. J Neural Transm. Vol. 116(2):203-12.
Abeta38, Aß38, A-beta38, A-ß38, Abeta 38, Aß 38, Ab38
Analytes tested using MSD assays: Abeta38 assay
Matrix tested: Human cerebrospinal fluid
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| Winkler, E., Hobson, S., Fukumori, A., Dümpelfeld, B., Luebbers, T., Baumann, K., Haass, C., Hopf, C., Steiner, H. (2009) Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase. Biochemistry. 2009 Feb 17;48(6):1183-97.
Amyloid precursor protein, APP, Abeta, Gamma secretase, g-secretase
Analytes tested using MSD assays: Antibodies for Abeta peptides were purchased from MSD
Matrix tested: Assay buffer
Special Techniques: In vitro gamma-secretase assays were done using a recombinant APP-based substrate, C100-His6, which generates Met-Abeta and AICD-His6
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| Abramowski, D., Wiederhold, K. Furrer, U., Jaton, A., Neuenschwander, A., Runser, M., Danner, S., Reichwald, J., Ammaturo, D., Staab, D., Stoeckli, M., Rueeger, H., Neumann, U., Staufenbiel, M. (2008) Dynamics of Ab Turnover and Deposition in Different APP Transgenic Mouse Models Following Gamma-Secretase Inhibition. J Pharmacol Exp Ther. Vol. 327(2):411-24.
Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40, Abeta42, Aß42, A-beta42, A-ß42, Abeta 42, Aß 42, Ab42, APP, amyloid precursor protein, sAPP, sAPPa, sAPPb, sAPPa, sAPPß, APP-alpha, APP-beta, APP alpha, APP beta
Analytes tested using MSD assays: Abeta40, Abeta42, soluble APPalpha, soluble APPbeta
Matrix tested: Transgenic mouse brain extracts, Abeta40 in human plasma, soluble APPalpha and soluble APPbeta in transgenic mouse brain extracts
Special Techniques: Formic acid extraction for peptide assays, Triton X-100 extraction for sAPP assays
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| Bibl, M., Lewczuk, P., Esselmann, H., Mollenhauer, B., Klafki, H.W., Welge, V., Wolf, S., Trenkwalder, C., Otto, M., Kornhuber, J., Wiltfang, J. (2008) CSF amyloid- 1-38 and 1-42 in FTD and AD: Biomarker performance critically depends on the detergent accessible fraction. Proteomics Clinical Applications. Vol. 2 (10-11): 548-1556.
Abeta38, Aß38, A-beta38, A-ß38, Abeta 38, Aß 38, Ab38
Analytes tested using MSD assays: Abeta38 assay
Matrix tested: Human cerebrospinal fluid
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| Björkqvist, M., Wild, E.J., Thiele, J., Silvestroni, A., Andre, R., Lahiri, N., Raibon, E., Lee, R.V., Benn, C.L., Soulet, D., Magnusson, A., Woodman, B., Landles, C., Pouladi, M.A., Hayden, M.R., Khalili-Shirazi, A., Lowdell, M.W., Brundin, P., Bates, G.P., Leavitt, B.R., Möller, T., Tabrizi, S.J. (2008) A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease. J Exp Med. Vol. Vol. 205(8):1869-77.
Interleukin, IL4, IL5, IL6, IL8, IL10, IL12, TNF-a, TNF-a, TNFa, TNFa, TNFalpha, Interferon, IFNg, IFNg, IFN-g, IFNgamma, IFN-g
Analytes tested using MSD assays: IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IFN-gamma, TNF-alpha, GM-CSF
Matrix tested: Human plasma
Note: Study tests the effect of inflammation associated with Huntington’s disease
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| Cacucci ,F., Yi M., Wills, T.J., Chapman, P., O'Keefe, J. (2008) Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model. PNAS Vol. 105 (22):7863-7868.
Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40, Abeta42, Aß42, A-beta42, A-ß42, Abeta 42, Aß 42, Ab42
Analytes tested using MSD assays: Abeta40, Abeta42
Matrix tested: Transgenic mouse brain extracts
Special Techniques: Guanidine hydrochloride extraction
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| Kadir, A., Andreasen, N., Almkvist, O., Wall, A., Forsberg, A., Engler, H., Hagman, G., Lärksäter, M., Winblad, B., Zetterberg, H., Blennow, K., Langström, B., Nordberg, A. (2008) Effect of phenserine treatment on brain functional activity and amyloid in Alzheimer's disease. Ann Neurol. Vol. 63(5):621-31.
APP, amyloid precursor protein, sAPP, sAPPa, sAPPb, sAPPa, sAPPß, APP-alpha, APP-beta, APP alpha, APP beta, CSF, Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40
Analytes tested using MSD assays: soluble APPalpha, soluble APPbeta, Abeta40
Matrix tested: Human cerebrospinal fluid
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| Kienlen-Campard, P., Tasiaux, B., Van Hees, J., Li, M., Huysseune, S., Sato, T., Fei, J.Z., Aimoto S., Courtoy, P.J., Smith, S.O., Constantinescu, S.N., Octave, J.N. (2008) Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs. J Biol Chem. Vol. 283(12): 7733-44.
APP, amyloid precursor protein, sAPP, sAPPa, sAPPb, sAPPa, sAPPß, APP-alpha, APP-beta, APP alpha, APP beta
Analytes tested using MSD assays: MSD soluble APPalpha, soluble APPbeta
Matrix tested: CHO cell supernatants
Note: Effect of mutations on the processing of APP by beta and gamma secretase enzymes was analyzed
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| Lannfelt, L., Blennow, K., Zetterberg, H., Batsman, S., Ames, D., Harrison, J., Masters, C.L., Targum, S., Bush, A.I., Murdoch, R., Wilson, J., Ritchie, C.W., PBT2-201-EURO study group. (2008) Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial. Lancet Neurol. Vol. 7(9):779-86.
Abeta40, Aβ40, A-beta40, A-β40, Abeta 40, Aβ 40, Ab40, Abeta42, Aβ42, A-beta42, A-β42, Abeta 42, Aβ 42, Ab42
Analytes tested using MSD assays: Abeta40, Abeta42
Matrix tested: Human cerebrospinal fluid
Note: Study is a phase II clinical trial
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| Lanz, TA., Salatto, C.T., Semproni, AR., Marconi, M., Brown, TM., Richter, KE., Schmidt, K., Nelson, FR., Schachter, JB., (2008) Peripheral elevation of IGF-1 fails to alter Ab clearance in multiple in vivo models. Biochemical Pharmacology. Vol. 75 (5):1093-1103.
Abeta, IGF-1, Abeta clearance, Tg2576, Tau
Analytes tested using MSD assays: Customer developed assay for embryonic myosin heavy chain (eMHC)
Matrix tested: Rat myoblast cell culture supernatants
Note: The effect of Insulin-like growth factor (IGF-1) on the levels of Abeta in CSF and plasma was studied in transgenic mice, rats and beagles
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| Lewczuk, P., Kamrowski-Kruck, H., Peters, O., Heuser, I., Jessen, F., Popp, J., Bürger, K., Hampel, H., Frölich, L., Wolf, S., Prinz, B., Jahn, H., Luckhaus, C., Perneczky, R., Hüll, M., Schröder, J., Kessler, H., Pantel, J., Gertz, H.J., Klafki, H.W., Kölsch, H., Reulbach, U. Esselmann, H., Maler, J.M., Bibl, M., Kornhuber, J., Wiltfang, J. (2008) Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study. Mol Psychiatry. Vol. 15(2):138-45.
APP, amyloid precursor protein, sAPP, sAPPa, sAPPb, sAPPa, sAPPß, APP-alpha, APP-beta, APP alpha, APP beta
Analytes tested using MSD assays: soluble APPalpha, soluble APPbeta
Matrix tested: Human cerebrospinal fluid
Note: This is a clinical study for the identification of diagnostic biomarkers for Alzheimer’s disease
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| Lewczuk P, Wiltfang J. (2008) Neurochemical dementia diagnostics: State of the art and research perspectives. Proteomics. Vol. 8(6):1292-301.
Alzheimer’s disease, Amyloid, Cerebrospinal fluid, CSF, Dementia, Tau, mild cognitive impairment
Note: In this article, the current state of the art in the field of diagnosis of different neurological dementing conditions has been reviewed together with the challenging research perspectives in this field. Cerebrospinal fluid biomarkers including amyloid beta peptides, phosphorylated Tau and total tau have been discussed in detail
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| Lloyd, E., Somera-Molina, K., Van Eldik, L.J., Watterson, D.M., Wainwright, M.S. (2008) Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury. J. Neuroinflammation. Vol. 30(5):28.
Interleukin, IL-1beta, IL-1b, IL1β, IL1b, IL6, TNF-α, TNFα, TNFa, TNF-a, TNFalpha
Analytes tested using MSD assays: MSD pro-inflammatory cytokine assays (IL-1β, IL-6, TNF-alpha and CCL2)
Matrix tested: Brain extracts from mouse model of closed head injury
Note: This paper studies the effect of a therapeutic drug on traumatic brain injury
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| Maler, J.M, Spitzer, P., Klafki, H.W, Esselmann, H., Bib,l M., Lewczuk, .P, Kornhuber, J., Herrmann, M., Wiltfang, J. (2008) Adherence-dependent shifts in the patterns of beta-amyloid peptides secreted by human mononuclear phagocytes. Brain Behav Immun. Vol. 22(7):1044-8.
APP, amyloid precursor protein, sAPP, sAPPa, sAPPb, sAPPa, sAPPß, APP-alpha, APP-beta, APP alpha, APP beta
Analytes tested using MSD assays: soluble APPalpha, soluble APPbeta
Matrix tested: PBMC culture supernatants
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| Rajendran, L., Schneider, A., Schlechtingen, G., Weidlich, S., Ries, J., Braxmeier, T., Schwille, P., Schulz, J.B., Schroeder, C., Simons, M., Jennings, G., Knölker, H.J., Simons, K. (2008) Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting. Science. Vol. 320(5875):520-3.
APP, amyloid precursor protein, sAPP, sAPPa, sAPPb, sAPPa, sAPPß, APP-alpha, APP-beta, APP alpha, APP beta, Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40, Abeta42, Aß42, A-beta42, A-ß42, Abeta 42, Aß 42, Ab42
Analytes tested using MSD assays: soluble APPalpha, soluble APPbeta, Abeta40, Abeta42
Matrix tested: HeLa cell culture supernatants
Note: This study is tests the effectiveness of a membrane-anchored version of a beta-secretase transition-state inhibitor by linking it to a sterol moiety
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| Riddell, D.R., Zhou, H., Atchison, K., Warwick, H.K., Atkinson, P.J., Jefferson, J., Xu, L., Aschmies, S., Kirksey, Y., Hu, Y., Wagner, E., Parratt, A., Xu, J., Li, Z., Zaleska, M.M., Jacobsen, J.S., Pangalos, M.N., Reinhart, P.H. (2008) Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels. J Neurosci. Vol. 28(45):11445-11453.
Apolipoprotein E
Analytes tested using MSD assays: User developed assay for total ApoE and ApoE4
Matrix tested: Cell culture media and transgenic mouse brain extracts
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| Tran, T.A., McCoy, M.K., Sporn, M.B., Tansey, M.G. (2008) The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection. J. Neuroinflammation. Vol. 5:14.
Interferon, IFNg, IFNgamma, IFN-γ, IFNγ, IFN-g, IL1b, IL-1b, Interleukin, IL1beta, IL-1β, IL1β, IL6, IL10, IL12, TNFa, TNF-a, TNFα, TNF-α, TNFalpha, KC, CXCL1
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-10, IL-12, KC/CXCL1, TNF-alpha
Matrix tested: Murine microglial cell culture supernatants
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| von Arnim, C.A., von Einem, B., Weber, P., Wagner, M., Schwanzar, D., Spoelgen, R., Strauss, W.L., Schneckenburger, H. (2008) Impact of cholesterol level upon APP and BACE proximity and APP cleavage. Biochem Biophys Res Commun. Vol. 370(2):207-12.
APP, amyloid precursor protein, sAPP, sAPPa, sAPPb, sAPPa, sAPPß, APP-alpha, APP-beta, APP alpha, APP beta
Analytes tested using MSD assays: soluble APPalpha, soluble APPbeta
Matrix tested: Human glioblastoma cell culture supernatants
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| Zetterberg, H., Andreasson, U., Hansson, O., Wu, G., Sankaranarayanan, S., Andersson, M.E., Buchhave, P., Londos, E., Umek, R.M., Minthon, L., Simon, A.J., Blennow, K. (2008) Elevated Cerebrospinal Fluid BACE1 Activity in Incipient Alzheimer Disease. Arch Neurol. Vol. 65(8):1102-1107.
Abeta40, Aβ40, A-beta40, A-β40, Abeta 40, Aβ 40, Ab40, APP, amyloid precursor protein, sAPP, sAPPa, sAPPb, sAPPα, sAPPβ, APP-alpha, APP-beta, APP alpha, APP beta
Analytes tested using MSD assays: soluble APPalpha, soluble APPbeta, Abeta40
Matrix tested: Human cerebrospinal fluid
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| Best, J.D., Smith, D.W., Reilly, M.A., O'Donnell, R., Lewis, H.D., Ellis, S., Wilkie, N., Rosahl, T.W., Laroque, P.A., Boussiquet-Leroux, C., Churcher, I., Atack, J.R., Harrison, T., Shearman, M.S. (2007) The Novel gamma-Secretase Inhibitor N-[cis-4-[(4- Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1- trifluoromethanesulfonamide (MRK-560) Reduces Amyloid Plaque Deposition without Evidence of Notch-Related Pathology in the Tg2576 Mouse. J Pharmacol Exp Ther. Vol. 320(2):552-8.
Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40, Abeta42, Aß42, A-beta42, A-ß42, Abeta 42, Aß 42, Ab42
Analytes tested using MSD assays: Abeta40, Abeta42
Matrix tested: Transgenic mouse brain extracts
Special Techniques: Guanidine hydrochloride extraction
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| Bibl, M., Mollenhauer, B., Lewczuk, P., Esselmann, H., Wolf, S, Trenkwalder, C., Otto, M., Stiens G., Rüther, E., Kornhuber, J., Wiltfang, J. (2007) Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias. Mol Psychiatry. Vol. 12:671-680.
Abeta38, Aß38, A-beta38, A-ß38, Abeta 38, Aß 38, Ab38
Analytes tested using MSD assays: Abeta38
Matrix tested: Human cerebrospinal fluid
Note: This is one of the largest CSF-based biomarker investigations on Abeta peptide patterns comparing the three major degenerative dementias - Alzheimer’s disease, Lewy Body dementia and frontotemporal dementia.
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| Cho, S., Hu, Y. (2007) Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival. Exp Neurol. Vol. 203(1):274-8.
Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40, Abeta42, Aß42, A-beta42, A-ß42, Abeta 42, Aß 42, Ab42
Analytes tested using MSD assays: Abeta40, Abeta42
Matrix tested: Cell culture media
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| Feyt, C., Pierrot, N., Tasiaux, B., Van Hees, J., Kienlen-Campard, P., Courtoy, P.J., Octave, J. (2007) Phosphorylation of APP695 at Thr668 decreases g-cleavage and extracellular Ab. Biochem Biophys Res Commun. Vol. 357:1004-1010.
APP, amyloid precursor protein, sAPP, sAPPa, sAPPb, sAPPa, sAPPß, APP-alpha, APP-beta, APP alpha, APP beta
Analytes tested using MSD assays: soluble APPalpha, soluble APPbeta
Matrix tested: CHO cell supernatants transfected with different forms of APP
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| Hussain, I., Hawkins, J., Harrison, D., Hille, C., Wayne, G., Cutler, L., Buck, T., Walter, D., Demont, E., Howes, C., Naylor, A., Jeffrey, P., Gonzalez, M.I., Dingwall, C., Michel, A., Redshaw, S., Davis, J.B. (2007) Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo. J Neurochem. Vol. 100(3):802-9.
APP, amyloid precursor protein, sAPP, sAPPa, sAPPb, sAPPa, sAPPß, APP-alpha, APP-beta, APP alpha, APP beta
Analytes tested using MSD assays: soluble APPalpha, soluble APPbeta
Matrix tested: Transgenic mouse brain extracts
Note: This paper studies the effect of a BACE1 inhibitor on APP cleavage
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| Page, R.M., Baumann,K., Tomioka, M., Pérez-Revuelta, B.I., Fukumori, A., Jacobsen, H., Flohr, A., Luebbers, T., Ozmen, L., Steiner, H., Haass, C. (2007) Generation of Ab38 and Ab42 Is Independently and Differentially Affected by Familial Alzheimer Disease-associated Presenilin Mutations and gamma-Secretase Modulation. J Biol Chem. Vol. 283(2):677-683.
Abeta38, Aß38, A-beta38, A-ß38, Abeta 38, Aß 38, Ab38, Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40, Abeta42, Aß42, A-beta42, A-ß42, Abeta 42, Aß 42, Ab42
Analytes tested using MSD assays: Abeta38, Abeta40, Abeta42 (customer developed assays on MSD plates)
Matrix tested: Cell culture medium
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| Riddell, D.R., Zhou, H., Comery, T.A., Kouranova, E., Lo, C.F., Warwick, H.K., Ring, R.H., Kirksey, Y., Aschmies, S., Xu, J., Kubek, K., Hirst, W.D., Gonzales, C., Chen, Y., Murphy, E., Leonard, S., Vasylyev, D., Oganesian, A., Martone, R.L., Pangalos, M.N., Reinhart, P.H., Jacobsen, J.S. (2007) The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease. Mol Cell Neurosci. Vol. 34(4):621-8.
Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40, Abeta42, Aß42, A-beta42, A-ß42, Abeta 42, Aß 42, Ab42
Analytes tested using MSD assays: Abeta40, Abeta42
Matrix tested: Transgenic mouse brain extracts
Special Techniques: Guanidine hydrochloride extraction
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| Shirotani, K., Tomioka, M., Kremmer, E., Haass, C., Steiner, H. (2007) Patholocial activity of familial Alzheimer’s disease-associated mutant presenilin can be executed by six different gamma-secretase complexes. Neurobiology of Disease Vol. 27:102-107.
Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40, Abeta42, Aß42, A-beta42, A-ß42, Abeta 42, Aß 42, Ab42
Analytes tested using MSD assays: Abeta40, Abeta42 (customer developed assays on MSD plates)
Matrix tested: Cell culture supernatants
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| Somera-Molina, K.C., Robin B., Somera, C.A., Anderson, C., Stine, C., Koh, S., Behanna, H.A., Van Eldik, L.J., Watterson, D.M., Wainwright, M.S. (2007) Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation. Epilepsia. Vol. 48(9):1785-800.
Interleukin, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, IL6, TNFalpha, TNFa, TNF-a, TNF-a, TNFa, tumor necrosis factor
Analytes tested using MSD assays:IL-1beta, IL-6, and TNF-alpha
Matrix tested: Rat brain homogenates (hippocampal homogenates)
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| Teeling, J.L., Felton, L.M., Deacon, R.M.J., Cunningham, C., Rawlins, J.N.P., Perry V.H. (2007) Sub-pyrogenic systemic inflammation impacts on brain and behavior, independent of cytokines. Brain Behavior and Immunity. Vol. 21(6):836-50.
IL1b, IL-1b, IL-1β, IL1β, IL1beta, IL6, Interleukin
Analytes tested using MSD assays: IL-1beta, IL-6 (measured using MSD Mouse ProInflammatory 7-plex Kit)
Matrix tested: Mouse plasma and tissue homogenates
Note: This study tested whether subpyrogenic doses of LPS can cause sufficient inflammation in rodents to impact brain communication and behavior
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| Best, J.D., Jay, M.T., Otu, F., Churcher, I., Reilly, M., Morentin-Gutierrez, P., Pattison, C., Harrison, T., Shearman, M.S., Atack, J.R. (2006) In vivo characterization of Abeta(40) changes in brain and cerebrospinal fluid using the novel gamma-secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) in the rat. J Pharmacol Exp Ther. Vol. 317(2):786-90.
Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40
Analytes tested using MSD assays: Abeta40
Matrix tested: Brain extracts from rats
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| Craft, J.M., Watterson, D. M., Van Eldik, L.J. (2006) Human amyloid beta - induced neuroinflammation is an early event in neurodegeneration. Glia. Vol. 53(5):484-490.
Interleukin, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, tumor necrosis factor, TNF-a, TNFa, TNFalpha, TNF-a, TNFa
Analytes tested using MSD assays: IL-1beta, TNF-alpha
Matrix tested: Mouse brain homogenates, mouse serum
Special Techniques: Snap-frozen mouse brain sections were homogenized in Hepes buffer with protease inhibitors by dounce and sonication
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| Goggi, J.L., Lewis, H.D., Mok, J., Harrison, T., Shearman, M.S., Atack, J.R., Best, J.D. (2006) A comparative assessment of g-secretase activity in transgenic and non-transgenic rodent brain. J. Neurosci Methods. Vol. 157(2): 246-252.
Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40
Analytes tested using MSD assays: Abeta40
Matrix tested: Mouse and rat brain extracts
Special Techniques: Frozen brain was homogenized in 10 volumes (w/v) of 0.2% diethylamine (DEA) containing 50 mM NaCl (pH 10) and protease inhibitors.
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| Laterza, O.F., Modur, V.R., Crimmins, D.L., Olander, J.V., Landt, Y., Lee, J., Ladenson, J.H. (2006) Identification of Novel Brain Biomarkers. Clin Chem. Vol. 52(9):1713-1721.
VLP1
Analytes tested using MSD assays: VLP-1 (customer developed assays on MSD plates)
Matrix tested: Human plasma
Note: This study was based on biomarker analysis in brain injury
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| Rajendran, L., Honsho, M., Zahn, T.R., Keller, P., Geiger, K.D., Verkade, P., Simons, K. (2006) Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc National Acad of Sci USA. Vol. 103(30):11172-7.
Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40, APP, amyloid precursor protein, sAPP, sAPPa, sAPPb, sAPPa, sAPPß, APP-alpha, APP-beta, APP alpha, APP beta
Analytes tested using MSD assays: Abeta40, soluble APPalpha, soluble APPbeta and APP (amyloid precursor protein)
Matrix tested: Exosome fractions from mouse cell culture medium
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| Ranaivo, H.R., Craft,J.M., Hu, W.H., Guo, L., Wing, L.K., Van Eldik, L.J., Watterson, D.M. (2006) Glia as a Therapeutic Target: Selective Suppression of Human Amyloid-Beta Induced Upregulation of Brain Proinflammatory Cytokine Production Attenuates Neurodegeneration. J Neuroscience. Vol. 26(2):662-670.
IL1b, IL-1b, IL-1β, IL1β, IL1beta, TNF-a, TNF-α, TNFa, TNFα, TNFalpha, Interleukin
Analytes tested using MSD assays: IL-1beta, TNF-alpha
Matrix tested:Mouse serum and brain homogenates
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| Best, J.D., Jay, M.T., Out, F., Ma, J., Nadin, A., Ellis, S., Lewis, H.D., Pattison, C., Reilly, M., Harrison, T., Shearman, M.S., Williamson, T.L., Atack, J.R. et al. (2005) Quantitative measurement of Changes in Amyloid-beta (40) in the Rat Brain and Cerebrospinal Fluid following Treatment with the gamma-Secretase Inhibitor LY-411575. J Pharmacol Exp Ther. Vol. 313(2):902-908.
Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40
Analytes tested using MSD assays: Abeta40 (customer developed assay on MSD avidin plate)
Matrix tested: Transgenic mouse brain extracts, rat brain extracts
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| Blennow, K. (2005) CSF biomarkers for Alzheimer's disease: use in early diagnosis and evaluation of drug treatment. Expert Rev Mol Diagn. Vol. 5(5):661-72.
Beta amyloid, cerebrospinal fluid, CSF, mass spectrometry, phosphorylated Tau, total Tau, proteomics, APP, ELISA, Meso Scale Discovery, Abeta
Note: In this article, the principle of detecting CSF biomarkers for Alzheimer’s disease, the different methods and techniques of detection and the rationale for using CSF biomarkers to study new drug candidates have been reviewed.
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| Hu, W., Ranaivo, H.R., Craft, J.M., Van Eldik, L.J., Watterson, D.M. (2005) Validation of the Neuroinflammation Cycle as a Drug Discovery Target Using Integrative Chemical Biology and Lead Compound Development with an Alzheimer's Disease-Related Mouse Model. Curr Alzheimer's Res. Vol. 2(2):197-205.
Interleukin, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, tumor necrosis factor, TNF-a, TNFa, TNFalpha, TNF-a, TNFa
Analytes tested using MSD assays: IL-1beta, TNF-alpha
Matrix tested: BV-2 mouse microglial cell culture supernatants
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| Wrigley, J.D., Schurov, I., Nunn, E.J., Martin, A.C., Clarke,E.E., Ellis, S., Bonnert, T.P., Shearman, M.S., Beher, D. (2005) Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity. J Biol Chem. Vol. 280(13):12523-35.
Abeta40, Aß40, A-beta40, A-ß40, Abeta 40, Aß 40, Ab40, Abeta42, Aß42, A-beta42, A-ß42, Abeta 42, Aß 42, Ab42
Analytes tested using MSD assays: Abeta40, Abeta42
Matrix tested: Cell culture supernatants
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* Pub Med (www.pubmed.gov) is a service of the U.S. National Library of Medicine and the National Institutes of Health |
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